Endocrine Abstracts

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease during 1–17 years.Materials and methods: i) Diagnostic: Hashimoto’s thyroiditis (HT): a) antithyroperoxydase antibodies (ATPO) cut-off 34 IU/ml. b) If ATPO=normal, thyroiditis was considered if high antithyroglobuline antibodies (T-ATG). c) Idiopathic mixedema (IM): hypothyroidism, no ATPO, no ATG, and no TRAB. ii) Patients: HT: 1196; T-ATG: 73; IM: 69. Women/me...

Introduction: The quantitative ultrasound (QUS) is an useful tool in the evaluation of the fragility fracture risk.Aim and study design: We performed the QUS fragility fracture risk groups (valided by the golden standard DXA) by a unifactorial analyze including the bone markers.Method: The cut offs used were: SI≤59U (high risk), SI≥83U (low risk), and medium risk with SI between 59 and 83U. The QUS analyze was performed...

Background: Cushing’s syndrome (CS) is associated with a hypercoagulable state and an increased risk for acute coronary syndromes, stroke, and deep vein thrombosis (DVT).Aim: To assess the prevalence of thrombotic events in a series of patients with CS.Patients and methods: Notes of 113 patients with CS were retrospectively reviewed.Results: Instable angina was diagnosed in ten women, aged 52.1±12.2...

Introduction: Even the differentiated thyroid neoplasm have good prognostic, there are some particular cases that become very aggressive in short time, with poor management.Aim: We report a female case diagnosed with invasive papillary thyroid carcinoma.Case report: Seventy-three-year old female was diagnosed at age of 71 with a right lobe thyroid nodule (of almost 6 cm). At that moment the computed tomography (CT) of the cervical ...

Introduction: Hashimoto’s Thyroiditis is a part of the spectrum of thyroid autoimmune diseases. Even the proper diagnosis is obtained by pathological exam; usually the detection of high serum antithyroid antibodies is enough to diagnose the disorder. It also represents the most frequent cause of hypothyroidism in non-iodine deficient areas. Nevertheless the presence of the antithyroid antibodies does not always correlates with thyroid dysfunction.Ai...

Introduction: The Gasser Ganglion is a large semi lunar-shaped ganglion of the trigeminal nerve. It contains the cells of origin of the most sensory fibers of the fifth cranial nerve.Aim: Our purpose is to describe a case where Gasser ganglion has an anatomic variant (near the sella turcica), mimicking a hypophyseal tumor.Case presentation: Of 17 years female patient has a history of bradispaniomenorrhea (menses at 30–50 days)...

Introduction: Incidentaloma is a randomly discovered tumor with no apparent secretor activity. The term is mainly used for hypophysis and adrenals. There are relatively few situations where a patient has more than one such mass.Aim: To present the case of a patient with three tumors: a pituitary mass and bilateral adrenal masses, with clinical manifestations of Cushing’s syndrome.Case report: A 37-year-old female patient who h...

Introduction: Paraneoplastic Cushing syndrome is a rare form of endogenous ACTH (adrenocorticotropic hormone) dependent hypercortisolism. In some cases no overt ACTH secretion tumor can be found, which is why steroidogenesis inhibitors, and bilateral adrenalectomy remain the main therapeutic options.Material and method: This is a case report investigated in several centers by performing biochemical, hormonal and imagery tests.Case ...

Aim: Most research teams analyze the evolution of patients with Hashimoto thyroiditis (HT) on syndromal basis, not on pathogenetic basis. Thus, most researchers refer to thyroid function evolution. In this study we tried to show how evolve the antithyroid antibodies. Therefore, we analyzed ATPO evolutive patterns.Method: (1) ATPO levels were analyzed in several accreditated Bucharest laboratories. (2) Only patients with minimum 3 investigations were cons...

Aim: The biological diagnostic of Hashimoto thyroiditis (HT) is based on higher than normal levels of antithyroperoxydase antibodies (ATPO). Our goal was to establish the cut-off limit of normality (the upper limit) for ATPO in our thyroid normal patients. This limit, and not that of the laboratory, should be used as diagnosis of Hashimoto thyroiditis.Material and method: 1. ATPO was investigated in patients with normal level of thyroid hormones (euthyro...